The Rejuvenate Set - A Gift of Mushroom Wellness

Experience Renewal with The Rejuvenate Set

Elevate your wellness journey to new heights with The Rejuvenate Set, a carefully crafted trio of medicinal mushroom products designed to empower your mornings, uplift your afternoons, and guide you towards peaceful evenings. These dynamic components combine to fortify your immune system, support your quest for longevity, and cultivate inner peace. Click on "THE INGREDIENTS" tab above to discover the individual benefits of each product and the powerful synergy that makes The Rejuvenate Set a true game-changer.

The Ingredients

Morning Shield with Turkey Tail Mushrooms

Begin your day with a robust defence against illness. Our Defend Now capsules, enriched with high levels of beta-glucans and specialized antioxidants (PSK and PSP), act as a formidable guardian for your immune system. They activate immune cells to combat pathogens effectively, protecting against viral infections and bolstering your body's natural defences. With Defend Now, your morning starts by boosting immune resilience. 

Turkey Tail Health Benefits 

Turkey Tail mushrooms are a crucial component of this daily mushroom routine, and their consumption in the morning offers unique health benefits. These mushrooms are rich in polysaccharides, particularly Polysaccharide Krestin (PSK), which has garnered attention for its exceptional immune-boosting properties [1]. PSK is so effective that Japan has classified it as an approved adjunct to cancer care, enhancing the well-being of individuals fighting cancer by fortifying their immune systems. 

Another significant compound in Turkey Tail is the polysaccharide-protein complex PSP, containing abundant beta-glucans [2]. Research reveals that these beta-glucans stimulate the production of nitric oxide and inducible nitric oxide synthase in macrophages. This activation equips macrophages to phagocytize and kill bacteria efficiently, potentially making Turkey Tail an antibiotic alternative for drug-resistant bacteria [3].

Turkey Tail also stands out for its ability to augment antibody production, particularly IgM and IgG, with IgG representing a significant portion of human serum antibodies [4]. These antibodies are essential for combating foreign pathogens and neutralizing and eliminating them from our bodies. This enhancement of antibody production is especially valuable when our bodies encounter novel pathogens or viruses, as it can extend our immunity, reducing the risk of reinfection over time.

Incorporating Turkey Tail mushrooms into your morning routine can set a strong foundation for overall immune health, enhancing your body's natural defences and safeguarding your well-being, particularly in the face of evolving health challenges.

Rejuvenate Blend: Antioxidant Mushroom Blend

As the day progresses, it's time to embrace the exceptional Rejuvenate Blend. This blend brings together six medicinal mushrooms, each renowned for its potent anti-aging compounds. Oyster, Chaga, Tremella, Lion's Mane, Shiitake, and Maitake mushroom extracts converge in a powerful combination, making them a formidable ally against various age-related conditions. The best part? You can effortlessly integrate this rejuvenating elixir into your daily routine by adding it to any food or beverage. 

Oyster Mushroom Benefits for Longevity

Oyster mushrooms are a nutritional powerhouse, offering various health benefits. These fungi have shown potential in improving different health markers, including glucose and lipid metabolism, blood pressure regulation, and protection against cardiovascular disease [5].

Oyster mushrooms can significantly reduce serum cholesterol levels, potentially lowering the risk of atherosclerosis, the buildup of arterial plaques that can lead to cardiovascular disease. In one study, Oyster consumption resulted in a 33% reduction in serum cholesterol and a 20% decrease in liver cholesterol content [6]. Oyster mushrooms improved levels of both LDL ("bad") and HDL ("good") cholesterol, promoting the excretion of harmful cholesterol [6]. Oyster mushrooms achieve this by reducing cholesterol absorption from the gut, similar to certain pharmaceutical drugs [6]. 

Antioxidant Powers of Chaga

Chaga mushroom extract’s impressive ORAC (Oxygen Radical Absorbance Capacity) value makes it exceptional at countering free radicals and protecting our body's antioxidant defences from oxidative stress. Oxidative stress, which results from an imbalance between free radicals and antioxidants, can harm cells and contribute to different diseases. Additionally, it can prompt the release of inflammatory mediators, intensifying inflammation in various medical conditions [14].

Radiant Skin with Tremella Mushrooms

Antioxidants are crucial for protecting our well-being by countering the harm caused by free radicals. Excessive free radicals can lead to oxidative stress, which can damage cells and result in health problems [12]. 

Tremella mushrooms stand out for their hydrating and antioxidant properties, with a long history of benefiting skin health, immune function, and disease prevention [13]. Recent research highlights their ability to reduce inflammation, aid wound healing, combat oxidation, slow aging, and shield against radiation [13]. Tremella polysaccharides are prized in skincare and cosmetics for their moisturizing qualities, making them valuable for both internal health and skin enhancement.

Lion’s Mane for Brain Health

As we age, our brain's ability to form and maintain cell connections decreases, causing mental function and memory decline. Lion's Mane contains hericenones and erinacines, which stimulate brain cell growth (neurogenesis) [14]. Research on mice found that these compounds reverse age-related memory decline by promoting brain cell growth in key areas—the cerebellum for movement and the hippocampus for memory [14]. Lion's Mane's impact on hippocampal cell growth is key to its memory-enhancing effects.

The fruiting body of Lion's Mane also contains isohericerinol A, boosting nerve growth factor (NGF) production [15]. NGF is crucial for nerve cell growth, development, and survival and inhibiting NGF impairs memory and brain function [16]. Lion's Mane may also safeguard nerve cells against damage caused by beta-amyloid plaques. These plaques may accumulate in the brain, disrupt normal cell function, and potentially trigger neurodegenerative diseases like Alzheimer's [17,18,19]. 

Maitake and Shiitake Mushroom Health Benefits 

Ergothioneine, a naturally occurring sulphur-based amino acid, plays a crucial role in cellular well-being and safeguarding against various health issues as a potent antioxidant. Since the human body doesn't produce it, integrating ergothioneine-rich supplements like Maitake and Shiitake mushroom extracts into your daily routine is vital for rejuvenation and preventing age-related complications. 

Life stressors can increase bodily stress levels, leading to oxidative stress, a known contributor to cardiovascular disease, diabetes, and neurodegenerative conditions [20]. Recent research highlights the numerous benefits of ergothioneine, including its potential to combat aging, reduce inflammation, and protect against oxidative stress. It's also associated with improved cognitive function, exercise performance, and various other health advantages. 

Chill Now with Reishi Mushroom Supplements

Evening Tranquility with Reishi: As the day winds down, invite serenity into your life with our Chill Nowcapsules. Featuring Reishi, often referred to as "herbal yoga," is a powerful adaptogen known for naturally reducing stress and anxiety. It calms the mind, strengthens the cardiovascular system, and supports better sleep. It has a long-standing reputation as the mushroom supplement of spiritual potency and immortality. With Chill Now, you can ease into the night with a sense of tranquility and prepare for restorative sleep.

Reishi's historical significance is rooted in its ability to promote calmness and improve sleep, which is integral to well-being [21]. Inadequate sleep is linked to various health issues, including cardiovascular disease, obesity, higher mortality rates, and diabetes [21]. 

Reishi enhances sleep by elevating sleep-promoting neurotransmitters and positively affecting gut microbiota, influencing sleep quality through the gut-brain axis [21].

Research demonstrates that Reishi mushroom extract can enhance sleep quality through microbiota-dependent and serotonin-related pathways. This underscores Reishi's potential as a natural solution for improving sleep and overall well-being. 

A study involving Reishi's fruiting body extract reveals that short-term supplementation may increase total sleep duration and non-rapid eye movement sleep, offering a more restful sleep experience [22]. This improvement could be attributed to Reishi's ability to regulate cytokines, particularly TNF-alpha, essential for sleep regulation.

The Research

References

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• [2] Shao-Hua Shi, Wen-Tao Yang, Ke-Yan Huang, Yan-Long Jiang, Gui-Lian Yang, Chun-Feng Wang, Yu Li. β-glucans from Coriolus versicolor protect mice against S. typhimurium challenge by activation of macrophages. International Journal of Biological Macromolecules, Volume 86, 2016, Pages 352-361. ISSN 0141-8130. https://doi.org/10.1016/j.ijbiomac.2016.01.058.

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• [5] Ratto D, Corana F, Mannucci B, Priori EC, Cobelli F, Roda E, Ferrari B, Occhinegro A, Di Iorio C, De Luca F, Cesaroni V, Girometta C, Bottone MG, Savino E, Kawagishi H, Rossi P. Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging. Nutrients. 2019 Mar 27;11(4):715. doi: 10.3390/nu11040715. PMID: 30934760; PMCID: PMC6521003.

• [6] Ryu SH, Hong SM, Khan Z, Lee SK, Vishwanath M, Turk A, Yeon SW, Jo YH, Lee DH, Lee JK, Hwang BY, Jung JK, Kim SY, Lee MK. Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus. Bioorg Med Chem Lett. 2021 Jan 1;31:127714. doi: 10.1016/j.bmcl.2020.127714. Epub 2020 Nov 25. PMID: 33246107.

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• [9] Zhang J, An S, Hu W, Teng M, Wang X, Qu Y, Liu Y, Yuan Y, Wang D. The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer's Disease Mouse Model. Int J Mol Sci. 2016 Nov 1;17(11):1810. doi: 10.3390/ijms17111810. PMID: 27809277; PMCID: PMC5133811.

• [10] Cheng JH, Tsai CL, Lien YY, Lee MS, Sheu SC. High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity. BMC Complement Altern Med. 2016 Jun 7;16:170. doi: 10.1186/s12906-016-1154-5. PMID: 27266872; PMCID: PMC4895996.

• [11] Hirsch KR, Smith-Ryan AE, Roelofs EJ, Trexler ET, Mock MG. Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. J Diet Suppl. 2017 Jan 2;14(1):42-53. doi: 10.1080/19390211.2016.1203386. Epub 2016 Jul 13. PMID: 27408987; PMCID: PMC5236007.

• [12] Xu YF. Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming. Int J Med Mushrooms. 2016;18(12):1083-1092. doi: 10.1615/IntJMedMushrooms.v18.i12.30. PMID: 28094746.

• [13] Koh JH, Kim KM, Kim JM, Song JC, Suh HJ. Antifatigue and antistress effect of the hot-water fraction from mycelia of Cordyceps sinensis. Biol Pharm Bull. 2003;26(5):691-694. doi:10.1248/bpb.26.691

• [14] Alhallaf W, Perkins LB. The Anti-Inflammatory Properties of Chaga Extracts Obtained by Different Extraction Methods against LPS-Induced RAW 264.7. Molecules. 2022 Jun 30;27(13):4207. doi: 10.3390/molecules27134207. PMID: 35807453; PMCID: PMC9268247.

• [15] Zheng W, Miao K, Liu Y, Zhao Y, Zhang M. Phenolics from Inonotus obliquus and their antioxidant and antitumor activities. Food Funct. 2018;9(7):3420-3431. doi:10.1039/c8fo00090a

• [16] Wang Y, Liu Y, Du X, Ma H, Yao J. Inonotus obliquus polysaccharide regulates gut microbiota of chronic pancreatitis in mice. AMB Express. 2020;10(1):130. doi:10.1186/s13568-020-01068-4

• [17] Choi JY, Shin KM, Kim HM, et al. Antioxidative effects of Phellinus linteus and red ginseng extracts on oxidative stress-induced DNA damage. J Med Food. 2006;9(1):35-42. doi:10.1089/jmf.2006.9.35

• [18] Zhou L, Yang HL, Zhou MQ, et al. The immunomodulatory effects of polysaccharides from Inonotus obliquus on macrophages through the TLR4 pathway, not the Dectin-1 pathway. Int J Biol Macromol. 2015;81:957-965. doi:10.1016/j.ijbiomac.2015.09.021

• [19] Ryu S, Kim HG, Kim JY, Kim SY, Cho KO. Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brain. J Med Food. 2018 Feb;21(2):174-180. doi: 10.1089/jmf.2017.4006. Epub 2017 Nov 1. PMID: 29091526.

• [20] Vigna L, Morelli F, Agnelli GM, Napolitano F, Ratto D, Occhinegro A, Di Iorio C, Savino E, Girometta C, Brandalise F, Rossi P. Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Evid Based Complement Alternat Med. 2019 Apr 18;2019:7861297. doi: 10.1155/2019/7861297. PMID: 31118969; PMCID: PMC6500611.

• [21] Yang, T., Nie, Z., Shu, H., Kuang, Y., Chen, X., Cheng, J., Yu, S., & Liu, H. (2020). The role of BDNF on neural plasticity in Depression. Frontiers in Cellular Neuroscience, 14. https://doi.org/10.3389/fncel.2020.00082 

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