What are Maitake Mushrooms?
Maitake mushrooms (Grifola frondosa), also known as "Hen of the Woods," are a type of medicinal fungi renowned for their impressive health benefits. These mushrooms are native to Japan and other parts of Asia and have been treasured for centuries for their potential therapeutic properties. Maitake mushrooms are characterized by their large, fan-shaped fruiting bodies, which resemble the fluffed feathers of a nesting hen. They are rich in essential nutrients, including vitamins, minerals, and amino acids, but their true claim to fame lies in their bioactive compounds. Research suggests that maitake mushrooms may possess potent immune-boosting properties, and they are often considered adaptogens that can help the body cope with stress and balance overall well-being. Additionally, Maitake mushrooms have been studied for their potential to support heart health, regulate blood sugar levels, and exhibit anti-inflammatory effects. With their fascinating array of health benefits, Maitake mushrooms continue to captivate the attention of both traditional medicine practitioners and modern researchers alike.
What are the Health Benefits of Maitake in Your Daily Routine?
The Maitake mushroom not only enhances immunity but also provides notable advantages for heart health and glucose regulation. Studies have revealed that Maitake can effectively reduce common symptoms of type 2 diabetes, such as high blood sugar, increased urine volume, and glucose in the urine, while also improving glucose tolerance levels. Additionally, Maitake has demonstrated its ability to improve lipid profiles by preventing lipid accumulation in the liver and reducing elevated lipid levels in the blood.
Incorporating Maitake mushrooms into your daily routine can offer a range of health benefits to support your overall well-being:
1) Strengthening immune function
2) Promoting cardiovascular health
3) Reducing inflammation
4) Potentially possessing anti-cancer properties
5) Supporting brain health by protecting against oxidative stress.
Maitake Mushroom: The Metabolism Booster
Research on maitake mushrooms has shown that a specific polysaccharide called GFPA (Grifola frondosa polysaccharide A) possesses notable health benefits, particularly in relation to obesity and inflammation . The study found that GFPA has anti-obesity and anti-inflammatory properties.
In the study, GFPA was isolated and its characteristics, including type, molecular weight, homogeneity, and structure, were determined. The researchers then tested the effects of GFPA on mice that were fed a high-fat diet (HFD), which is a common model for inducing obesity and related health issues.
The results revealed several positive effects of GFPA administration in HFD-treated mice :
1) Weight and blood glucose reduction: GFPA efficiently decreased body weight and blood glucose concentration in the mice.
2) Counteracting hyperlipidemia: GFPA helped to counteract the harmful elevation of lipid levels in the blood.
3) Improved adipose tissue health: GFPA decreased the size of adipocytes (fat cells) and ameliorated inflammatory infiltration in the different types of white adipose tissue.
4) Alleviating liver issues: GFPA reduced steatosis (fatty liver) and fat accumulation in the livers of HFD-fed mice, while also reducing inflammatory infiltration in the liver.
5) Improved liver function: GFPA decreased the concentrations of aspartate aminotransferase and alanine aminotransferase, which are markers of liver damage, in the sera and livers of HFD-treated mice.
6) Reduced pro-inflammatory factors: GFPA helped to decrease the levels of pro-inflammatory factors in both the blood and liver of HFD-treated mice.
7) Regulation of lipid metabolism: GFPA achieved its anti-obesity effects, in part, by inhibiting ceramide levels in the HFD-treated mice. Ceramides are lipid molecules associated with obesity-related health issues.
The study also identified the mechanism by which GFPA exerts its effects. It was found that GFPA modulates chronic inflammation through the Toll-like receptor 4/nuclear factor kappa-B signaling pathway. This pathway plays a crucial role in the body's immune response and inflammation regulation.
Overall, the research indicates that GFPA from maitake mushrooms has strong potential as a natural treatment for obesity, primarily due to its ability to regulate lipid metabolism and combat chronic inflammation. These findings support the use of GFPA as a promising option for managing obesity and its associated health risks.
Maitake Mushrooms May Reduce Cardiovascular Risk Factors
One research study aimed to investigate the effectiveness of maitake mushrooms in preventing the increase of liver and serum lipids in rats with hyperlipidemia . The study used two groups of rats: one fed a high-cholesterol diet and the other given a diet fortified with 20% maitake mushroom dried powder...
Maitake May Support Blood Sugar Regulation
In type 2 diabetes mellitus (T2DM), the cells of the body stop responding as efficiently to insulin and insulin resistance ensues. Insulin is a hormone made by the pancreas that allows our bodies to use sugar from carbohydrates for energy or for storage to be used in the future. With insulin resistance, the level of insulin production is increased, before the pancreas tires and it decreases, resulting in T2DM...
Maitake Mushrooms as Immunomodulators
In recent times, researchers have been investigating the potential health advantages of maitake mushrooms and have discovered several bioactive compounds within them that could bolster immune function, reduce inflammation, and even impede the growth of cancer cells....
Maitake Mushrooms are a Significant Source of Ergothioneine
Mushrooms, such as shiitake, oyster, maitake, reishi, and lion's mane, are known to be rich sources of ergothioneine, a potent antioxidant compound. Studies have highlighted the potential health benefits of ergothioneine, particularly in areas like aging...
Maitake May Play a Role in Men’s Health
Prostate cancer can be effectively treated, especially when detected early. However, a resistant form called hormone-refractory prostate cancer poses challenges as chemotherapy tends to have limited effectiveness . To enhance treatment outcomes, researchers are exploring alternatives to chemotherapy and chemo-sensitizing methods [7,8].
One such study focused on beta-glucan, a polysaccharide found in the maitake mushroom, known for its adaptogenic properties that help the body combat physical and mental ailments caused by chronic stress . Maitake is abundant in minerals, vitamins, and antioxidants, making it valuable for addressing various health conditions . The study revealed that the beta-glucan in maitake demonstrated a cytotoxic effect on prostate cancer cells, inhibiting their growth and migration . Moreover, it was found to sensitize the cells to chemotherapy, enhancing the efficiency of prostate cancer treatment, particularly in hormone-refractory cases where chemotherapy alone has limited efficacy . This promising research highlights the potential of maitake mushroom-derived beta-glucan as a valuable addition to prostate cancer treatment strategies.
How to Use Maitake Mushrooms?
In addition to enjoying Maitake mushrooms in various dishes like soups, stews, and stir-fries, there are other ways to maximize their health benefits and achieve therapeutic doses. Mushroom extract blends are available in powder form, making them easy to incorporate into your daily routine. You can simply add them to your morning coffee or tea, blend them into smoothies, or use them as an ingredient in cooking to add a delightful depth and earthy flavor to your dishes.
For those who prefer taking supplements, Maitake mushroom extract capsules offer a convenient option to reap the mushroom's health benefits without the need to cook with it. When using any mushroom product, it's essential to follow the recommended dosage instructions and maintain consistency in consumption. Consistency is key to obtaining the full benefits of any supplement.
Maitake Mushroom Extract Powder
Eversio Wellness offers two powerful mushroom extract blends containing Maitake:
Recommended Dosages of Maitake Mushrooms
For optimal consumption, Eversio Wellness advises individuals to consume ½ tsp (1000 mg) of either the BALANCE blend or REJUVENATE blend per day.
The BALANCE blend boasts an impressive composition of 45% beta-D-glucans, 6% terpenes, 0.8% triterpenes, and 0.08% ergothioneine. The REJUVENATE blend contains 37% beta-D-glucans, 3.8% terpenes, 3.8% triterpenes, 0.6% betulinic acid, and 0.1% ergothioneine.
Where to Buy Quality Maitake Mushroom Supplement
In the vast market of medicinal mushrooms, it becomes imperative to prioritize awareness of the product's composition to ensure the utmost potency. At Eversio Wellness, their commitment lies in offering exclusively 100% fruiting body mushroom extracts, maintaining a transparent approach towards consumers by providing Certificates of Analysis (COAs) for each product. These COAs serve as a reassurance, scientifically confirming the claimed percentages of beneficial constituents through meticulous lab testing. Furthermore, the COAs also verify the absence of heavy metals and microbial contaminants, assuring customers of receiving the finest mushroom supplements available.
Maitake Mushroom Health and Safety
Maitake mushroom supplements have gained popularity due to their potential health benefits and immune-boosting properties. These supplements are generally considered safe for most people when taken in appropriate doses. Maitake mushrooms are rich in vitamins, minerals, and antioxidants, which can support overall health and well-being. Additionally, their beta-glucan content may aid in strengthening the immune system and promoting cardiovascular health. However, it is essential to purchase supplements from reputable sources to ensure their quality and purity. As with any supplement, individuals should consult their healthcare provider before adding maitake mushroom supplements to their regimen, especially if they have underlying health conditions or are taking other medications. Pregnant or breastfeeding women should also seek medical advice before using these supplements. By following recommended dosages and professional guidance, maitake mushroom supplements can be a safe and beneficial addition to a balanced and healthy lifestyle.
-  Kubo K, Nanba H. The effect of maitake mushrooms on liver and serum lipids. Altern Ther Health Med. 1996 Sep;2(5):62-6. PMID: 8795938.
-  Kubo K, Nanba H. Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I. Biol Pharm Bull. 1997 Jul;20(7):781-5. doi: 10.1248/bpb.20.781. PMID: 9255420.
-  Jiang X, Hao J, Zhu Y, Liu Z, Li L, Zhou Y, Li Y, Teng L, Wang D. The anti-obesity effects of a water-soluble glucan from Grifola frondosa via the modulation of chronic inflammation. Front Immunol. 2022 Jul 28;13:962341. doi: 10.3389/fimmu.2022.962341. PMID: 35967316; PMCID: PMC9367694.
-  Wu JY, Siu KC, Geng P. Bioactive Ingredients and Medicinal Values of Grifola frondosa (Maitake). Foods. 2021 Jan 5;10(1):95. doi: 10.3390/foods10010095. PMID: 33466429; PMCID: PMC7824844.
-  Horio H, Ohtsuru M. Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats. J Nutr Sci Vitaminol (Tokyo). 2001 Feb;47(1):57-63. doi: 10.3177/jnsv.47.57. PMID: 11349892.
-  Manohar V, Talpur NA, Echard BW, Lieberman S, Preuss HG. Effects of a water-soluble extract of maitake mushroom on circulating glucose/insulin concentrations in KK mice. Diabetes Obes Metab. 2002 Jan;4(1):43-8. doi: 10.1046/j.1463-1326.2002.00180.x. PMID: 11874441.
-  Finkelstein MP, Aynehchi S, Samadi AA, Drinis S, Choudhury MS, Tazaki H, Konno S. Chemosensitization of carmustine with maitake beta-glucan on androgen-independent prostatic cancer cells: involvement of glyoxalase I. J Altern Complement Med. 2002 Oct;8(5):573-80. doi: 10.1089/107555302320825084. PMID: 12470438.
-  Fullerton SA, Samadi AA, Tortorelis DG, Choudhury MS, Mallouh C, Tazaki H, Konno S. Induction of apoptosis in human prostatic cancer cells with beta-glucan (Maitake mushroom polysaccharide). Mol Urol. 2000 Spring;4(1):7-13. PMID: 10851301.
-  Cronkleton, E. (2017, October 12). Maitake mushroom: Risks, benefits, and more. Healthline. Retrieved November 14, 2022, from https://www.healthline.com/health/food-nutrition/maitake-mushroom#TOC_TITLE_HDR_1
-  Cheah IK, Halliwell B. Ergothioneine; antioxidant potential, physiological function and role in disease. Biochim Biophys Acta. 2012 May;1822(5):784-93.
-  Kim SY, Yoo SM, Hyun JW, Jeon YJ, Kim YS, Koh YS, Jeon BH. Ergothioneine Suppresses Airway Inflammation in a Mouse Model of Allergic Asthma. J Korean Med Sci. 2017 May;32(5):877-884. doi: 10.3346/jkms.2017.32.5.877. PMID: 28378529; PMCID: PMC5380539.
-  Cheah IK, Tang RM, Yew TS, Lim KH, Halliwell B. Administration of pure ergothioneine to healthy human subjects: uptake, metabolism, and effects on biomarkers of oxidative damage and inflammation. Antioxid Redox Signal. 2017 Sep 1;27(7):606-621.
-  Fovet T, Guilhot C, Delobel P, Chopard A, Py G, Brioche T. Ergothioneine Improves Aerobic Performance Without Any Negative Effect on Early Muscle Recovery Signaling in Response to Acute Exercise. Front Physiol. 2022 Feb 9;13:834597. doi: 10.3389/fphys.2022.834597. PMID: 35222093; PMCID: PMC8864143. https://doi.org/10.1016/j.bbr.2011.11.017.
-  Fovet T, Guilhot C, Delobel P, Chopard A, Py G, Brioche T. Ergothioneine Improves Aerobic Performance Without Any Negative Effect on Early Muscle Recovery Signaling in Response to Acute Exercise. Front Physiol. 2022 Feb 9;13:834597. doi: 10.3389/fphys.2022.834597. PMID: 35222093; PMCID: PMC8864143.
-  Cheah IK, Halliwell B. Ergothioneine, recent developments. Redox Biol. 2021 Jun;42:101868. doi: 10.1016/j.redox.2021.101868. Epub 2021 Jan 26. PMID: 33558182; PMCID: PMC8113028.
-  Guggenheim AG, Wright KM, Zwickey HL. Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology. Integr Med (Encinitas). 2014 Feb;13(1):32-44. PMID: 26770080; PMCID: PMC4684115.
-  Aguilera-Braico DM, Balogh GA. CD3Ɛ immune restorative ability induced by Maitake Pro4x in immunosupressed BALBc mice. BMC Res Notes. 2022 Sep 23;15(1):307. doi: 10.1186/s13104-022-06201-1. PMID: 36138418; PMCID: PMC9502923.
-  Mirończuk-Chodakowska I, Kujawowicz K, Witkowska AM. Beta-Glucans from Fungi: Biological and Health-Promoting Potential in the COVID-19 Pandemic Era. Nutrients. 2021 Nov 6;13(11):3960. doi: 10.3390/nu13113960. PMID: 34836215; PMCID: PMC8623785.