The Awaken Set - A Gift of Mushroom Wellness

Unlock Your Potential with the Awaken Set: A Mushroom Wellness Regimen

Are you ready to supercharge your mornings, power through your afternoons, and wind down your evenings with a sense of clarity and well-being? Eversio Wellness is thrilled to introduce the Awaken Set, a powerful trio of products designed to transform your mornings, afternoons, and evenings. 

This curated mushroom supplement set is designed to give you a daily routine that supports your overall health and vitality. This set combines the goodness of Turkey Tail, Lion's Mane, Cordyceps, and Chaga mushroom extracts to provide you with a comprehensive daily regimen for optimal health and vitality. Click on "THE INGREDIENTS" tab above to explore the unique attributes of each mushroom in this set and delve into the synergy that makes these products work in perfect unison.

The Ingredients

Morning Bliss with The 3 Mushroom Blend

The 3 Mushroom Blend is your perfect morning companion. It's a potent medicinal mushroom blend of Turkey Tail, Lion's Mane, and Cordyceps extracts in a convenient powdered form. This blend is incredibly versatile, making it easy to incorporate into your daily routine. Whether you prefer a cup of morning coffee, tea, overnight oats, or a nourishing smoothie, add a spoonful of this mushroom blend for an instant boost.  

This morning elixir is designed to provide many mushroom blend benefits; boost immune strength, support brain health, and deliver caffeine-free energy to kickstart your day. Say goodbye to those jitters; 3 Mushroom Blend will awaken your senses gently and keep you energized throughout the day.

Turkey Tail for Immune Strength and Resilience

Turkey Tail is renowned for being a powerful immune-boosting mushroom. Packed with powerful antioxidants and immune-enhancing polysaccharides, this mushroom extract is a game-changer in the wellness world. By incorporating Turkey Tail into your morning routine with our 3 Mushroom Blend, you're arming your body with the strength it needs to tackle the day ahead. 

As mentioned, Turkey Tail extracts are rich in compounds that have been studied for their potential to support the immune system. One of these compounds, Polysaccharide Krestin (PSK), has gained attention due to its ability to enhance the immune system's health [1]. In fact, Japan has approved PSK as a complement to cancer care because it has been shown to benefit individuals fighting cancer [1]. 

Turkey Tail mushrooms also contain another essential compound called PSP, packed with beta-glucans. Research suggests these beta-glucans can activate macrophages, special cells that combat pathogens [2]. This activation helps macrophages efficiently target and eliminate bacteria, and some studies even propose using Turkey Tail as an alternative to antibiotics for certain drug-resistant bacteria. 

Macrophages have specific receptors that interact with beta-glucans, further enhancing their role in pathogen elimination [3]. When these receptors engage with beta-glucans, a chain reaction begins, eliminating harmful microorganisms. Additionally, Turkey Tail has been found to boost the production of antibodies, specifically IgM and IgG [4]. These antibodies play a crucial role in our immune system because IgG makes up a significant part of our serum antibodies and is mobilized to neutralize and remove foreign pathogens from our body [4]. Talk about mushroom-powered wellness. 

Cognitive Support with Lion’s Mane 

Lion's Mane is often called the "brain mushroom," and for good reason. This remarkable fungus promotes neurogenesis, the creation of new brain cells, and enhances cognitive function. As part of the 3 Mushroom Blend, Lion's Mane ensures that you stay sharp and focused throughout the day while supporting your brain's long-term health. 

As we age, our brain's ability to form and maintain connections between its cells gradually decreases, leading to a decline in mental function and memory. Lion's Mane contains two unique compounds called hericenones and erinacines [5]. These compounds have been found to help the growth of brain cells; a process known as neurogenesis [5]. A study involving mice discovered that taking standardized extracts of hericenones and erinacines could reverse the decline in their memory that comes with age [5]. 

The study showed this was connected to more brain cell growth in certain areas. The cerebellar region deals with movement, while the hippocampus is crucial for learning and memory. Lion's Mane's ability to stimulate the growth of brain cells in the hippocampus is thought to be the reason it can help counteract memory decline. 

The fruiting body of Lion's Mane also contains isohericerinol A, a bioactive compound that increases the production of nerve growth factor (NGF) [6]. NGF is essential for nerve cell growth, development, and survival. Studies have shown that blocking NGF can impair memory and reduce brain activity [7]. Furthermore, Lion's Mane has shown it may protect nerve cells from damage caused by proteins called beta-amyloid plaques, which can build up in the brain, disrupt normal cell function, and potentially lead to neurodegenerative diseases like Alzheimer’s [8,9,10]. 

Cordyceps: Energy Booster

Say goodbye to caffeine-induced jitters! Cordyceps is a natural energy booster that invigorates without the side effects of caffeine. In the 3 Mushroom Blend, Cordyceps joins the morning lineup to provide sustained energy, helping you kickstart your day with vigour and vitality.

Cordyceps is Mother Nature’s all-natural performance enhancer. Cordyceps is commonly used to help athletes amp up their energy, stamina, and endurance without caffeine or addictive substances. Research has shown that Cordyceps can improve our body's energy systems by increasing ATP levels, which are like tiny energy molecules in our cells [11].

In fact, studies completed on mice have found that Cordyceps can make them swim for more extended periods without getting tired [12]. So, Cordyceps has shown the potential to prolong time to exhaustion and alleviate fatigue during exercise. And it's not just about feeling less tired; Cordyceps also seems to reduce various fatigue-related biochemical parameters in our body like lactic acid, urea nitrogen, creatine kinase, and more [12]. Simultaneously, Cordyceps boosted antioxidants and glycogen levels in our muscles and liver.  

Cordyceps isn't just about energy; it's also promising for dealing with burnout [13]. One crucial mechanism revolves around Cordyceps' capacity to enhance cellular energy production due to bioactive compounds such as cordycepin and adenosine [13]. By increasing the synthesis of ATP, Cordyceps promotes mitochondrial function and improves energy metabolism, combating the fatigue associated with burnout. Experience natural energy with Cordyceps in your mushroom-based daily routine.

Afternoon Resilience with Protect Now: Chaga Antioxidant Support

As the day progresses, it's essential to maintain your energy and focus, making the afternoon the perfect time to shield your body from the stresses of daily life. Enter Protect Now, a product that safeguards your well-being in the afternoon. These Organic Chaga 8:1 Dual Extract Capsules provide powerful anti-inflammatory and antioxidant support. By taking Protect Now, you're helping protect your DNA while facing the challenges of the day head-on. With the support of Chaga, you can maintain your resilience and tackle your tasks with confidence.

Chaga's impressive ORAC (Oxygen Radical Absorbance Capacity) value makes it exceptional at countering free radicals and protecting our body's antioxidant defences from oxidative stress. Oxidative stress, which results from an imbalance between free radicals and antioxidants, can harm cells and contribute to different diseases. Additionally, it can prompt the release of inflammatory mediators, intensifying inflammation in various medical conditions [14].

In-depth research has revealed the high antioxidant content of Chaga, including phenols, flavonoids, and melanin, which effectively counteract free radicals and neutralize reactive oxygen species (ROS) [15,16]. Moreover, Chaga enhances the activity of crucial antioxidant enzymes in the body, like superoxide dismutase (SOD) and catalase, which are instrumental in breaking down harmful ROS and protecting cells from damage [17]. 

Furthermore, Chaga's antioxidant properties extend to restraining the production of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), which are known contributors to oxidative stress [18]. By mitigating these factors, Chaga mushrooms are a robust defence against oxidative stress, offering a strong protective mechanism for overall health and well-being. 

Evening Serenity with Focus Now

When evening falls, and it's time to unwind, you need something to help you relax and prepare for a peaceful night's sleep. Focus Now, an organic Lion’s Mane supplement is the perfect solution. Lion's Mane is known for promoting neurogenesis, the production of new neurons in the brain. By incorporating this into your evening routine, you're setting the stage for quality sleep and supporting your cognitive health. As you plan your evening and reflect on the day, Focus Now will help you achieve a state of serene well-being. 

As mentioned, Lion’s Mane has shown evidence of improving neurogenesis and cognitive health, leading to increased mental clarity. However, research also points to Lion’s Mane’s ability to enhance the quality of sleep and mood disorders. 

The hippocampus, a brain area linked to emotions and memory, plays a key role in mood disorders like depression. Research consistently shows that people with mood disorders often have smaller hippocampi, which affects their brain circuitry. In 2018, a study shed light on Lion's Mane's potential to reduce anxiety and depression, possibly by boosting the growth of new brain cells in the hippocampus [19].

To delve further into Lion's Mane's benefits, a 2019 study focused on overweight patients with depression, anxiety, sleep problems, and binge-eating issues. After eight weeks of Lion’s Mane daily mushroom supplements, the study measured brain-derived neurotrophic factor (BDNF) and its precursor pro-BDNF in their serum [20]. The results showed increased pro-BDNF levels and significant improvements in depression, anxiety, and sleep quality [20]. While BDNF's mechanisms are complex, it plays a crucial role in maintaining existing neurons and promoting the growth of new ones [21]. Lion’s Mane brain support seems to know no bounds.

The Research

References

• [1] PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. Medicinal Mushrooms (PDQ®): Patient Version. 2022 Jul 29. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK424937/

• [2] Shao-Hua Shi, Wen-Tao Yang, Ke-Yan Huang, Yan-Long Jiang, Gui-Lian Yang, Chun-Feng Wang, Yu Li. β-glucans from Coriolus versicolor protect mice against S. typhimurium challenge by activation of macrophages. International Journal of Biological Macromolecules, Volume 86, 2016, Pages 352-361. ISSN 0141-8130. https://doi.org/10.1016/j.ijbiomac.2016.01.058.

  (https://www.sciencedirect.com/science/article/pii/S0141813016300605)

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• [4] Habtemariam S. Trametes versicolor (Synn. Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy. Biomedicines. 2020 May 25;8(5):135. doi: 10.3390/biomedicines8050135. PMID: 32466253; PMCID: PMC7277906.

• [5] Ratto D, Corana F, Mannucci B, Priori EC, Cobelli F, Roda E, Ferrari B, Occhinegro A, Di Iorio C, De Luca F, Cesaroni V, Girometta C, Bottone MG, Savino E, Kawagishi H, Rossi P. Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging. Nutrients. 2019 Mar 27;11(4):715. doi: 10.3390/nu11040715. PMID: 30934760; PMCID: PMC6521003.

• [6] Ryu SH, Hong SM, Khan Z, Lee SK, Vishwanath M, Turk A, Yeon SW, Jo YH, Lee DH, Lee JK, Hwang BY, Jung JK, Kim SY, Lee MK. Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus. Bioorg Med Chem Lett. 2021 Jan 1;31:127714. doi: 10.1016/j.bmcl.2020.127714. Epub 2020 Nov 25. PMID: 33246107.

• [7] Conner JM, Franks KM, Titterness AK, Russell K, Merrill DA, Christie BR, Sejnowski TJ, Tuszynski MH. NGF is essential for hippocampal plasticity and learning. J Neurosci. 2009 Sep 2;29(35):10883-9. doi: 10.1523/JNEUROSCI.2594-09.2009. PMID: 19726646; PMCID: PMC2765804.

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• [9] Zhang J, An S, Hu W, Teng M, Wang X, Qu Y, Liu Y, Yuan Y, Wang D. The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer's Disease Mouse Model. Int J Mol Sci. 2016 Nov 1;17(11):1810. doi: 10.3390/ijms17111810. PMID: 27809277; PMCID: PMC5133811.

• [10] Cheng JH, Tsai CL, Lien YY, Lee MS, Sheu SC. High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity. BMC Complement Altern Med. 2016 Jun 7;16:170. doi: 10.1186/s12906-016-1154-5. PMID: 27266872; PMCID: PMC4895996.

• [11] Hirsch KR, Smith-Ryan AE, Roelofs EJ, Trexler ET, Mock MG. Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. J Diet Suppl. 2017 Jan 2;14(1):42-53. doi: 10.1080/19390211.2016.1203386. Epub 2016 Jul 13. PMID: 27408987; PMCID: PMC5236007.

• [12] Xu YF. Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming. Int J Med Mushrooms. 2016;18(12):1083-1092. doi: 10.1615/IntJMedMushrooms.v18.i12.30. PMID: 28094746.

• [13] Koh JH, Kim KM, Kim JM, Song JC, Suh HJ. Antifatigue and antistress effect of the hot-water fraction from mycelia of Cordyceps sinensis. Biol Pharm Bull. 2003;26(5):691-694. doi:10.1248/bpb.26.691.

• [14] Alhallaf W, Perkins LB. The Anti-Inflammatory Properties of Chaga Extracts Obtained by Different Extraction Methods against LPS-Induced RAW 264.7. Molecules. 2022 Jun 30;27(13):4207. doi: 10.3390/molecules27134207. PMID: 35807453; PMCID: PMC9268247.

• [15] Zheng W, Miao K, Liu Y, Zhao Y, Zhang M. Phenolics from Inonotus obliquus and their antioxidant and antitumor activities. Food Funct. 2018;9(7):3420-3431. doi:10.1039/c8fo00090a

• [16] Wang Y, Liu Y, Du X, Ma H, Yao J. Inonotus obliquus polysaccharide regulates gut microbiota of chronic pancreatitis in mice. AMB Express. 2020;10(1):130. doi:10.1186/s13568-020-01068-4

• [17] Choi JY, Shin KM, Kim HM, et al. Antioxidative effects of Phellinus linteus and red ginseng extracts on oxidative stress-induced DNA damage. J Med Food. 2006;9(1):35-42. doi:10.1089/jmf.2006.9.35

• [18] Zhou L, Yang HL, Zhou MQ, et al. The immunomodulatory effects of polysaccharides from Inonotus obliquus on macrophages through the TLR4 pathway, not the Dectin-1 pathway. Int J Biol Macromol. 2015;81:957-965. doi:10.1016/j.ijbiomac.2015.09.021

• [19] Ryu S, Kim HG, Kim JY, Kim SY, Cho KO. Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brain. J Med Food. 2018 Feb;21(2):174-180. doi: 10.1089/jmf.2017.4006. Epub 2017 Nov 1. PMID: 29091526.

• [20] Vigna L, Morelli F, Agnelli GM, Napolitano F, Ratto D, Occhinegro A, Di Iorio C, Savino E, Girometta C, Brandalise F, Rossi P. Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Evid Based Complement Alternat Med. 2019 Apr 18;2019:7861297. doi: 10.1155/2019/7861297. PMID: 31118969; PMCID: PMC6500611.

• [21] Yang, T., Nie, Z., Shu, H., Kuang, Y., Chen, X., Cheng, J., Yu, S., & Liu, H. (2020). The role of BDNF on neural plasticity in Depression. Frontiers in Cellular Neuroscience, 14. https://doi.org/10.3389/fncel.2020.00082 

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