CHAGA

• CANCER: Suk-kyung Ko, Mirim Jin, Myoung-yun Pyo. (2011, October 11). Inonotus obliquus extracts suppress antigen-specific IgE production through the modulation of Th1/Th2 cytokines in ovalbumin-sensitized mice. ScienceDirect. https://www.sciencedirect.com/science/article/abs/pii/S0378874111005009?via%3Dihub
• CANCER: Arata S, Watanabe J, Maeda M, Yamamoto M, Matsuhashi H, Mochizuki M, Kagami N, Honda K, Inagaki M. Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice. Heliyon. 2016 May 12;2(5):e00111. doi: 10.1016/j.heliyon.2016.e00111. PMID: 27441282; PMCID: PMC4946216.
• CANCER: Yun CW, Lee SH. The Roles of Autophagy in Cancer. Int J Mol Sci. 2018 Nov 5;19(11):3466. doi: 10.3390/ijms19113466. PMID: 30400561; PMCID: PMC6274804.
• BREAST CANCER: Lee MG, Kwon YS, Nam KS, Kim SY, Hwang IH, Kim S, Jang H. Chaga mushroom extract induces autophagy via the AMPK-mTOR signaling pathway in breast cancer cells. J Ethnopharmacol. 2021 Jun 28;274:114081. doi: 10.1016/j.jep.2021.114081. Epub 2021 Mar 30. PMID: 33798660.
• IMMUNOMODULATION: Yeon-Ran Kim. (2005, September). Immunomodulatory Activity of the Water Extract from Medicinal Mushroom Inonotus obliquus. National Library of Medicine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774877/

Antioxidants & DNA Damage

• DNA CHANGES: ScienceDaily. (2021, January 14). Even skin shielded from the sun accumulates genomic DNA changes from UV light. ScienceDaily. Retrieved November 3, 2022, from https://www.sciencedaily.com/releases/2021/01/210114163929.htm 
• ANTI-OXIDANT: Jehane Ibrahim Eid, Swabhiman Mohanty, Biswadeep Das, J. I. (2020, January 1). Genoprotective effects of Chaga mushroom (Inonotus obliquus) polysaccharides in UVB-exposed embryonic zebrafish (Danio rerio) through coordinated expression of DNA repair genes. bioRxiv. https://www.biorxiv.org/content/10.1101/2020.06.19.161182v1.full
• ANTI-OXIDANT: UHN Staff, U. (2020, March 25). Chaga Benefits That Are Not Found in Any Other Herb. University Health News. https://universityhealthnews.com/daily/nutrition/chaga-benefits-that-are-not-found-in-any-other-herb/

Diabetes

• ANTI-DIABETIC EFFECTS: Cong Wang, Zhongqin Chen, Yuxiang Pan, Xudong Gao, Haixia Chen. (2017, October). Anti-diabetic effects of Inonotus obliquus polysaccharides-chromium (III) complex in type 2 diabetic mice and its sub-acute toxicity evaluation in normal mice. ScienceDirect. https://www.sciencedirect.com/science/article/abs/pii/S0278691517300078?via%3Dihub
• ANTI-DIABETIC EFFECTS: Wang, C., Chen, Z., Pan, Y., Gao, X., & Chen, H. (2017). Anti-diabetic effects of Inonotus obliquus polysaccharides-chromium (III) complex in type 2 diabetic mice and its sub-acute toxicity evaluation in normal mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 108(Pt B), 498–509. https://doi.org/10.1016/j.fct.2017.01.007

Gastrointestinal Conditions