CHAGA MUSHROOMS (INONOTUS OBLIQUUS)
Immune Support
Suk-kyung Ko, Mirim Jin, Myoung-yun Pyo. (2011, October 11). Inonotus obliquus extracts suppress antigen-specific IgE production through the modulation of Th1/Th2 cytokines in ovalbumin-sensitized mice. ScienceDirect. https://www.sciencedirect.com/science/article/abs/pii/S0378874111005009?via%3Dihub
Arata S, Watanabe J, Maeda M, Yamamoto M, Matsuhashi H, Mochizuki M, Kagami N, Honda K, Inagaki M. Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice. Heliyon. 2016 May 12;2(5):e00111. doi: 10.1016/j.heliyon.2016.e00111. PMID: 27441282; PMCID: PMC4946216.
Yun CW, Lee SH. The Roles of Autophagy in Cancer. Int J Mol Sci. 2018 Nov 5;19(11):3466. doi: 10.3390/ijms19113466. PMID: 30400561; PMCID: PMC6274804.
Lee MG, Kwon YS, Nam KS, Kim SY, Hwang IH, Kim S, Jang H. Chaga mushroom extract induces autophagy via the AMPK-mTOR signaling pathway in breast cancer cells. J Ethnopharmacol. 2021 Jun 28;274:114081. doi: 10.1016/j.jep.2021.114081. Epub 2021 Mar 30. PMID: 33798660.
Yeon-Ran Kim. (2005, September). Immunomodulatory Activity of the Water Extract from Medicinal Mushroom Inonotus obliquus. National Library of Medicine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774877/
Antioxidants & DNA Damage
ScienceDaily. (2021, January 14). Even skin shielded from the sun accumulates genomic DNA changes from UV light. ScienceDaily. Retrieved November 3, 2022, from https://www.sciencedaily.com/releases/2021/01/210114163929.htm
Jehane Ibrahim Eid, Swabhiman Mohanty, Biswadeep Das, J. I. (2020, January 1). Genoprotective effects of Chaga mushroom (Inonotus obliquus) polysaccharides in UVB-exposed embryonic zebrafish (Danio rerio) through coordinated expression of DNA repair genes. bioRxiv. https://www.biorxiv.org/content/10.1101/2020.06.19.161182v1.full
UHN Staff, U. (2020, March 25). Chaga Benefits That Are Not Found in Any Other Herb. University Health News. https://universityhealthnews.com/daily/nutrition/chaga-benefits-that-are-not-found-in-any-other-herb/
Lin J, Lu YY, Shi HY, Lin P. Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), Polysaccharides Alleviate Photoaging by Regulating Nrf2 Pathway and Autophagy. Int J Med Mushrooms. 2023;25(10):49-64. doi: 10.1615/IntJMedMushrooms.2023049657.
PMID: 37830196.
Blood Sugar Support
Cong Wang, Zhongqin Chen, Yuxiang Pan, Xudong Gao, Haixia Chen. (2017, October). Anti-diabetic effects of Inonotus obliquus polysaccharides-chromium (III) complex in type 2 diabetic mice and its sub-acute toxicity evaluation in normal mice. ScienceDirect. https://www.sciencedirect.com/science/article/abs/pii/S0278691517300078?via%3Dihub
Wang, C., Chen, Z., Pan, Y., Gao, X., & Chen, H. (2017). Anti-diabetic effects of Inonotus obliquus polysaccharides-chromium (III) complex in type 2 diabetic mice and its sub-acute toxicity evaluation in normal mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 108(Pt B), 498–509. https://doi.org/10.1016/j.fct.2017.01.007
Digestive Health
mushroomreferences.com. (2015, October 14). Chaga mushroom extract inhibits oxidative DNA damage in lymphocytes of patients with inflammatory bowel disease – mushroomreferences.com. http://mushroomreferences.com/2015/10/14/chaga-mushroom-extract-inhibits-oxidative-dna-damage-in-lymphocytes-of-patients-with-inflammatory-bowel-disease/
Choi SY, Hur SJ, An CS, Jeon YH, Jeoung YJ, Bak JP, Lim BO. Anti-inflammatory effects of Inonotus obliquus in colitis induced by dextran sodium sulfate. J Biomed Biotechnol. 2010;2010:943516. doi: 10.1155/2010/943516. Epub 2010 Mar 10. PMID: 20300439; PMCID: PMC2840610.
Joint Support
Alhallaf W, Perkins LB. The Anti-Inflammatory Properties of Chaga Extracts Obtained by Different Extraction Methods against LPS-Induced RAW 264.7. Molecules. 2022 Jun 30;27(13):4207. doi: 10.3390/molecules27134207. PMID: 35807453; PMCID: PMC9268247.
Se Young Choi, Sun Jin Hur, Chi Sun An, Yun Hui Jeon, Young Jun Jeoung, Jong Phil Bak, And Beong Ou Lim. (2010, March 10). Anti-Inflammatory Effects of Inonotus obliquus in Colitis Induced by Dextran Sodium Sulfate. Hindawi. https://www.hindawi.com/journals/bmri/2010/943516/
Konrad A. Szychowski, Bartosz Skóra, Tadeusz Pomianek, Jan Gmiński. Inonotus obliquus – from folk medicine to clinical use. Journal of Traditional and Complementary Medicine, Volume 11, Issue 4, 2021, Pages 293-302, ISSN 2225-4110, https://doi.org/10.1016/j.jtcme.2020.08.003 (https://www.sciencedirect.com/science/article/pii/S2225411020309809)
Vincenti, M.P., Brinckerhoff, C.E. Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Res Ther 4, 157 (2002). https://doi.org/10.1186/ar401
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