Studies + Research + References
CORDYCEPS - (CORDYCEPS MILITARIS)
- INTEGRATIVE ONCOLOGY: Guggenheim, A. G., Wright, K. M., & Zwickey, H. L. (2014). Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology. Integrative medicine (Encinitas, Calif.), 13(1), 32–44.
- HIGH-INTENSITY EXERCISE: Hirsch, K. R., Smith-Ryan, A. E., Roelofs, E. J., Trexler, E. T., & Mock, M. G. (2017). Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. Journal of dietary supplements, 14(1), 42–53. https://doi.org/10.1080/19390211.2016.1203386
- ALZHEIMER'S DISEASE: Protective role of Cordyceps militaris in Aβ1–42-induced Alzheimer’s disease in vivo Mei Tong He, Ah Young Lee, Ji Hyun Kim, Chan Hum Park, Yu Su Shin, Eun Ju Cho - Food Sci Biotechnol. 2019 Jun; 28(3): 865–872. Published online 2018 Dec 4. doi: 10.1007/s10068-018-0521-z PMCID: PMC6484065
- MEMORY: Lee, B., Park, J., Park, J. et al. Cordyceps Militaris improves neurite outgrowth in Neuro2A cells and reverses memory impairment in rats. Food Sci Biotechnol 20, 1599–1608 (2011). https://doi.org/10.1007/s10068-011-0221-4
- EXERCISE PERFORMANCE: Eunhyun Choi, Junsang Oh & Gi-Ho Sung (2020) Beneficial Effect of Cordyceps militaris on Exercise Performance via Promoting Cellular Energy Production, Mycobiology, 48:6, 512-517, DOI: 10.1080/12298093.2020.1831135
- DEPRESSION: Yu-En Lin, Yi-Chun Chen, Kuan-Hung Lu, Yun-Ju Huang, Suraphan Panyod, Wei-Ting Liu, Shu-Hui Yang, Yun-Sheng Lu, Mei-Hsing Chen, Lee-Yan Sheen, Antidepressant-like effects of water extract of Cordyceps militaris (Linn.) Link by modulation of ROCK2/PTEN/Akt signaling in an unpredictable chronic mild stress-induced animal model, Journal of Ethnopharmacology, Volume 276, 2021, 114194, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2021.114194. (https://www.sciencedirect.com/science/article/pii/S0378874121004219)
- COPD: Yang, Lei et al. “Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease.” Experimental and therapeutic medicine vol. 15,3 (2018): 2731-2738. doi:10.3892/etm.2018.5777
- SEXUAL DYSFUNCTION: Jiraungkoorskul, Kanitta, and Wannee Jiraungkoorskul. “Review of Naturopathy of Medical Mushroom, Ophiocordyceps Sinensis, in Sexual Dysfunction.” Pharmacognosy reviews vol. 10,19 (2016): 1-5. doi:10.4103/0973-7847.176566
- IMMUNOMODULATION: Shin, S., et al., Role of Cordycepin and Adenosine on the Phenotypic Switch of Macrophages via Induced Anti-inflammatory Cytokines. Immune Netw, 2009. 9 (6): p. 255-64.
- NATURAL HISTORY: Greenwood, V. The worms that cost $20,000 a kilo. BBC Future 2016 [cited 2020 March 20]
- LIVER CANCER: Guo, Z., et al., Cordycepin suppresses the migration and invasion of human liver cancer cells by downregulating the expression of CXCR4. Int J Mol Med, 2020. 45(1): p. 141-150.
- WEIGHT LOSS: An, Y., et al., Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats. Lipids Health Dis, 2018. 17(1): p. 276.
- ASTHMA: Zheng, Y., L. Li, and T. Cai, Cordyceps polysaccharide ameliorates airway inflammation in an ovalbumin-induced mouse model of asthma via TGF-β1/Smad signaling pathway. Respir Physiol Neurobiol, 2020. 276: p. 103412.
- ASTHMA: Wang, N., et al., Herbal Medicine Cordyceps sinensis Improves Health-Related Quality of Life in Moderate-to-Severe Asthma. Evidence-Based Complementary and Alternative Medicine, 2016. 2016: p. 6134593.
- TYPE 2 DIABETES: Zhao, H., et al., Antioxidant and Hypoglycemic Effects of Acidic-Extractable Polysaccharides from Cordyceps militaris on Type 2 Diabetes Mice. Oxidative Medicine and Cellular Longevity, 2018. 2018: p. 9150807.
- DEPRESSION: Li, B., et al., 3'-Deoxyadenosine (Cordycepin) Produces a Rapid and Robust Antidepressant Effect via Enhancing Prefrontal AMPA Receptor Signaling Pathway. Int J Neuropsychopharmacol, 2016. 19(4).
- OVERVIEW: Lin B, Li S. Cordyceps as an Herbal Drug. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 5. Available from: https://www.ncbi.nlm.nih.gov/books/NBK92758/
- HIGH-INTENSITY EXERCISE: Katie R. Hirsch, Abbie E. Smith-Ryan, Erica J. Roelofs, Eric T. Trexler, & Meredith G. Mock. (2016, July 13). Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. Taylor & Francis. https://www.tandfonline.com/doi/full/10.1080/19390211.2016.1203386?cookieSet=1
- IMMUNOSTIMULATORY: Gitishree Das, G., Han-Seung Shin, Gerardo Leyva-Gómez, María L. Del Prado-Audelo, Hernán Cortes, Yengkhom Disco Singh, Manasa Kumar Panda, Abhay Prakash Mishra, Manisha Nigam, Sarla Saklani, Praveen Kumar Chaturi, Miquel Martorell, Natália Cruz-Martins, Vineet Sharma, Neha Garg, Rohit Sharma, & Jayanta Kumar Patra. (2021). Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials. Frontiers. https://www.frontiersin.org/articles/10.3389/fphar.2020.602364/full
- ANTIBIOTIC: Jong Ho Koh, J. H., Hyung Joo Suh, & Tae Seok Ahn. (2003, April 1). Hot-water extract from mycelia of Cordyceps sinensis as a substitute for antibiotic growth promoters. SpringerLink. https://link.springer.com/article/10.1023/A:1022893000418?error=cookies_not_supported&code=f2361ee5-ae6d-42ef-8c0f-5a8c81bce5f7
- EXERCISE ENDURANCE: Rajesh Kumar, P.S. Negi, Bhagwat Singh, Govindasamy Ilavazhagan, Kalpana Bhargava, Niroj Kumar Sethy. (2011, July 14). Cordyceps sinensis promotes exercise endurance capacity of rats by activating skeletal muscle metabolic regulators. ScienceDirect. https://www.sciencedirect.com/science/article/abs/pii/S0378874111002923?via%3Dihub
- AEROBIC CAPACITY + RESPIRATORY FUNCTION: Xiao Yi, X., Huang Xi-zhen, & Zhu Jia-shi. (2004, September 1). Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis (Cs-4) in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers. SpringerLink. https://link.springer.com/article/10.1007/BF02836405?error=cookies_not_supported&code=66eb0adc-62e2-411b-b9d7-f273a5368f42
- ANTI-AGING: Deng-Bo Ji, Jia Ye,Chang-Ling Li, Yu-Hua Wang, Jiong Zhao, Shao-Qing Cai. (2008, September 19). Antiaging effect of Cordyceps sinensis extract. Wiley Online Library. https://onlinelibrary.wiley.com/doi/10.1002/ptr.2576
- IMMUNE SYSTEM FUNCTION: Jian Gao, Ze-Qin Lian, Ping Zhu, Hai-Bo Zhu. (2011, June). Lipid-lowering effect of cordycepin (3’-deoxyadenosine) from Cordyceps militaris on hyperlipidemic hamsters and rats. National Library of Medicine. https://pubmed.ncbi.nlm.nih.gov/21882527/
- RHEUMATOID ARTHRITIS: Noh EM, Kim JS, Hur H, Park BH, Song EK, Han MK, Kwon KB, Yoo WH, Shim IK, Lee SJ, Youn HJ, Lee YR. Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts. Rheumatology (Oxford). 2009 Jan;48(1):45-8. doi: 10.1093/rheumatology/ken417. PMID: 19056796.
- ANTI-INFLAMMATORY: Tan L, Song X, Ren Y, Wang M, Guo C, Guo D, Gu Y, Li Y, Cao Z, Deng Y. Anti-inflammatory effects of cordycepin: A review. Phytother Res. 2020 Oct 8. doi: 10.1002/ptr.6890. Epub ahead of print. PMID: 33090621.
- HIGH-INTENSITY EXERCISE: Hirsch KR, Smith-Ryan AE, Roelofs EJ, Trexler ET, Mock MG. Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. J Diet Suppl. 2017 Jan 2;14(1):42-53. doi: 10.1080/19390211.2016.1203386. Epub 2016 Jul 13. PMID: 27408987; PMCID: PMC5236007.
- RESPIRATORY FUNCTION: Yi, X., Xi-zhen, H. & Jia-shi, Z. Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis (Cs-4) in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers. Chin. J. Integr. Med. 10, 187–192 (2004)
- ASTHMA: Wang N, Li J, Huang X, Chen W, Chen Y. Herbal Medicine Cordyceps sinensis Improves Health-Related Quality of Life in Moderate-to-Severe Asthma. Evid Based Complement Alternat Med. 2016;2016:6134593. doi: 10.1155/2016/6134593. Epub 2016 Dec 5. PMID: 28050193; PMCID: PMC5165155.
- COPD: Yu X, Mao Y, Shergis JL, Coyle ME, Wu L, Chen Y, Zhang AL, Lin L, Xue CC, Xu Y. Effectiveness and Safety of Oral Cordyceps sinensis on Stable COPD of GOLD Stages 2-3: Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med. 2019 Apr 3;2019:4903671. doi: 10.1155/2019/4903671. PMID: 31073318; PMCID: PMC6470429.
- COPD: Yang L, Jiao X, Wu J, Zhao J, Liu T, Xu J, Ma X, Cao L, Liu L, Liu Y, Chi J, Zou M, Li S, Xu J, Dong L. Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease. Exp Ther Med. 2018 Mar;15(3):2731-2738. doi: 10.3892/etm.2018.5777. Epub 2018 Jan 19. PMID: 29456676; PMCID: PMC5795554.
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COPD: Springer J, Scholz FR, Peiser C, Groneberg DA, Fischer A. SMAD-signaling in chronic obstructive pulmonary disease: transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke. Biol Chem. 2004 Jul;385(7):649-53. doi: 10.1515/BC.2004.080. PMID: 15318814.