SHIITAKE - (LENTINULA EDODES)

Auto-Immune Disease & Tumors

• ANTI-TUMOR: Finimundy TC, Gambato G, Fontana R, Camassola M, Salvador M, Moura S, Hess J, Henriques JA, Dillon AJ, Roesch-Ely M. Aqueous extracts of Lentinula edodes and Pleurotus sajor-caju exhibit high antioxidant capability and promising in vitro antitumor activity. Nutr Res. 2013 Jan;33(1):76-84. doi: 10.1016/j.nutres.2012.11.005. Epub 2012 Dec 6. PMID: 23351413.

Blood Pressure & Cholesterol

• CHOLESTEROL: Fukushima, M., Ohashi, T., Fujiwara, Y., Sonoyama, K., & Nakano, M. (2001). Cholesterol-Lowering Effects of Maitake (Grifola frondosa) Fiber, Shiitake (Lentinus edodes) Fiber, and Enokitake (Flammulina velutipes) Fiber in Rats. Experimental Biology and Medicine, 226(8), 758–765. https://doi.org/10.1177/153537020222600808

Inflammation & Arthritis

• ANTI-TNF-A (ANTI-ARTHRITIC): Xu X, Yasuda M, Nakamura-Tsuruta S, Mizuno M, Ashida H. β-Glucan from Lentinus edodes inhibits nitric oxide and tumor necrosis factor-α production and phosphorylation of mitogen-activated protein kinases in lipopolysaccharide-stimulated murine RAW 264.7 macrophages. J Biol Chem. 2012 Jan 6;287(2):871-8. doi: 10.1074/jbc.M111.297887. Epub 2011 Nov 18. PMID: 22102286; PMCID: PMC3256862.
• IMMUNOMODULATION: Mallard B, Leach D. N, Wohlmuth H, Tiralongo J. Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake. PLoS ONE. 2019;14(11).