SHIITAKE MUSHROOMS (LENTINULA EDODES)

Immune Support

Finimundy TC, Gambato G, Fontana R, Camassola M, Salvador M, Moura S, Hess J, Henriques JA, Dillon AJ, Roesch-Ely M. Aqueous extracts of Lentinula edodes and Pleurotus sajor-caju exhibit high antioxidant capability and promising in vitro antitumor activity. Nutr Res. 2013 Jan;33(1):76-84. doi: 10.1016/j.nutres.2012.11.005. Epub 2012 Dec 6. PMID: 23351413.

Dai X, Stanilka JM, Rowe CA, Esteves EA, Nieves C Jr, Spaiser SJ, Christman MC, Langkamp-Henken B, Percival SS. Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults.
J Am Coll Nutr. 2015;34(6):478-87. doi: 10.1080/07315724.2014.950391. Epub 2015 Apr 11. PMID: 25866155.

Zi Y, Jiang B, He C, Liu L. Lentinan inhibits oxidative stress and inflammatory cytokine production induced by benzo(a)pyrene in human keratinocytes. J Cosmet Dermatol. 2020 Feb;19(2):502-507. doi: 10.1111/jocd.13005. Epub 2019 May 28. PMID: 31135098.

Heart Health

Fukushima, M., Ohashi, T., Fujiwara, Y., Sonoyama, K., & Nakano, M. (2001). Cholesterol-Lowering Effects of Maitake (Grifola frondosa) Fiber, Shiitake (Lentinus edodes) Fiber, and Enokitake (Flammulina velutipes) Fiber in Rats. Experimental Biology and Medicine, 226(8), 758–765. https://doi.org/10.1177/153537020222600808

Yoon KN, Alam N, Lee JS, Cho HJ, Kim HY, Shim MJ, Lee MW, Lee TS. Antihyperlipidemic Effect of Dietary Lentinus edodes on Plasma, Feces and Hepatic Tissues in Hypercholesterolemic Rats. Mycobiology. 2011 Jun;39(2):96-102. doi: 10.4489/MYCO.2011.39.2.096. Epub 2011 Jun 16. PMID: 22783084; PMCID: PMC3385098.

Spim SRV, Pistila AMH, Pickler TB, Silva MT, Grotto D. Effects of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Bars on Lipid and Antioxidant Profiles in Individuals with Borderline High Cholesterol: A Double-Blind Randomized Clinical Trial. Int J Med Mushrooms. 2021;23(7):1-12. doi: 10.1615/IntJMedMushrooms.2021038773. PMID: 34375514.

Dai X, Stanilka JM, Rowe CA, Esteves EA, Nieves C Jr, Spaiser SJ, Christman MC, Langkamp-Henken B, Percival SS. Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults. J Am Coll Nutr. 2015;34(6):478-87. doi: 10.1080/07315724.2014.950391. Epub 2015 Apr 11. PMID: 25866155.

Joint Support

Xu X, Yasuda M, Nakamura-Tsuruta S, Mizuno M, Ashida H. β-Glucan from Lentinus edodes inhibits nitric oxide and tumor necrosis factor-α production and phosphorylation of mitogen-activated protein kinases in lipopolysaccharide-stimulated murine RAW 264.7 macrophages. J Biol Chem. 2012 Jan 6;287(2):871-8. doi: 10.1074/jbc.M111.297887. Epub 2011 Nov 18. PMID: 22102286; PMCID: PMC3256862.

Mallard B, Leach D. N, Wohlmuth H, Tiralongo J. Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake. PLoS ONE. 2019;14(11).

Oral Health

Avinash J, Vinay S, Jha K, Das D, Goutham BS, Kumar G. The Unexplored Anticaries Potential of Shiitake Mushroom. Pharmacogn Rev. 2016 Jul-Dec;10(20):100-104. doi: 10.4103/0973-7847.194039. PMID: 28082791; PMCID: PMC5214552.